Alessandro Aiuti Selected Research

pegademase bovine (pegADA)

1/2020	Urogenital Abnormalities in Adenosine Deaminase Deficiency.
11/2017	Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients.
2/2012	Alterations in the adenosine metabolism and CD39/CD73 adenosinergic machinery cause loss of Treg cell function and autoimmunity in ADA-deficient SCID.
7/2007	Burkitt's lymphoma in a patient with adenosine deaminase deficiency-severe combined immunodeficiency treated with polyethylene glycol-adenosine deaminase.
12/2003	Gene therapy for adenosine deaminase deficiency.

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Alessandro Aiuti Research Topics

Disease

40	Severe combined immunodeficiency due to adenosine deaminase deficiency 02/2024 - 05/2002
34	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 02/2024 - 06/2002
16	Wiskott-Aldrich Syndrome 04/2024 - 08/2002
10	Infections 10/2022 - 09/2002
8	COVID-19 01/2023 - 01/2020
8	Chronic Granulomatous Disease 11/2022 - 01/2009
7	Metachromatic Leukodystrophy (Sulfatide Lipidosis) 04/2023 - 08/2013
6	Inflammation (Inflammations) 01/2023 - 10/2016
5	Mucopolysaccharidosis I (Hurler Syndrome) 05/2024 - 01/2017
5	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2023 - 01/2020
4	Neoplasms (Cancer) 10/2022 - 07/2007
4	Reinfection 01/2022 - 09/2004
3	Virus Diseases (Viral Diseases) 10/2022 - 09/2002
3	Disease Progression 01/2021 - 01/2017
3	Pneumonia (Pneumonitis) 01/2021 - 10/2020
2	Rare Diseases (Rare Disease) 01/2023 - 01/2018
2	Primary Immunodeficiency Diseases 10/2022 - 03/2015
2	Colitis 10/2022 - 01/2022
2	Neutropenia 01/2022 - 01/2009
2	Mucopolysaccharidoses 01/2022 - 11/2018
2	Hemorrhage 05/2019 - 01/2019
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2019 - 01/2017
2	Thalassemia 01/2019 - 01/2019
2	Hematologic Neoplasms (Hematological Malignancy) 01/2016 - 08/2012
2	Eczema 05/2014 - 09/2008
1	Kyphosis 05/2024
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 04/2024
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 04/2024
1	Clubfoot (Talipes Equinovarus) 04/2023
1	Encephalitis (Encephalitis, Rasmussen) 01/2023
1	Diabetes Insipidus 01/2023
1	Gout 01/2023
1	Multiple Sclerosis 01/2023
1	Immune System Diseases (Immune Disorders) 01/2023
1	Cryopyrin-Associated Periodic Syndromes 01/2023
1	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2023
1	West Nile Fever 01/2023
1	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 01/2023
1	Human Influenza (Influenza) 10/2022
1	Bronchiectasis 10/2022
1	Lung Diseases (Lung Disease) 10/2022
1	Pancreatic Neoplasms (Pancreatic Cancer) 10/2022
1	Paralysis (Palsy) 02/2022
1	Genetic Risk Score 01/2022
1	Eosinophilia 01/2022
1	Vasculitis (Vasculitides) 01/2022
1	Thrombocytopenia (Thrombopenia) 01/2022
1	Polyneuropathies (Polyneuropathy) 01/2022
1	Dermatitis 01/2022
1	Stroke (Strokes) 01/2021

Drug/Important Bio-Agent (IBA)

36	Adenosine DeaminaseIBA 02/2024 - 06/2002
14	purineIBA 11/2017 - 09/2004
13	AutoantibodiesIBA 01/2023 - 02/2012
10	CytokinesIBA 01/2021 - 09/2002
7	EnzymesIBA 01/2019 - 05/2002
6	Proteins (Proteins, Gene)FDA Link 01/2019 - 11/2006
5	pegademase bovine (pegADA)FDA Link 01/2020 - 12/2003
4	Biomarkers (Surrogate Marker)IBA 04/2024 - 01/2020
4	Busulfan (Busulfex)FDA Link 02/2024 - 01/2009
4	AntibodiesIBA 01/2023 - 06/2012
3	Interferon Type IIBA 01/2023 - 11/2018
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2022 - 09/2002
3	HLA Antigens (Human Leukocyte Antigens)IBA 01/2022 - 01/2017
3	Immunoglobulin E (IgE)IBA 01/2022 - 11/2018
3	Cerebroside-Sulfatase (Arylsulfatase A)IBA 01/2021 - 08/2013
3	Wiskott-Aldrich Syndrome ProteinIBA 05/2019 - 05/2014
3	Adenosine (Adenocard)FDA LinkGeneric 11/2017 - 04/2008
2	Rituximab (Mabthera)FDA Link 01/2022 - 01/2021
2	Monoclonal AntibodiesIBA 01/2022 - 01/2021
2	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2021 - 10/2016
2	Sirolimus (Rapamycin)FDA Link 01/2020 - 01/2018
2	Iduronidase (alpha-L-Iduronidase)IBA 01/2019 - 01/2017
2	Hemoglobins (Hemoglobin)IBA 01/2019 - 01/2019
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2018 - 03/2015
2	ChemokinesIBA 10/2016 - 09/2002
2	Interleukin-2 (IL2)IBA 03/2013 - 09/2002
2	DNA (Deoxyribonucleic Acid)IBA 03/2012 - 09/2002
2	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 07/2007 - 12/2003
1	Growth Hormone (Somatotropin)IBA 01/2023
1	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 01/2023
1	Interleukin-1 (Interleukin 1)IBA 01/2023
1	P-2 (P 2)IBA 10/2022
1	Messenger RNA (mRNA)IBA 02/2022
1	2019-nCoV Vaccine mRNA-1273IBA 02/2022
1	VaccinesIBA 02/2022
1	COVID-19 VaccinesIBA 02/2022
1	Actin-Related Protein 2-3 Complex (Arp2 3 Complex)IBA 01/2022
1	Immunoglobulin A (IgA)IBA 01/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2022
1	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2022
1	B-Cell Activation Factor ReceptorIBA 01/2022

Therapy/Procedure

17	Hematopoietic Stem Cell Transplantation 05/2024 - 05/2007
11	Therapeutics 04/2023 - 09/2002
7	Enzyme Replacement Therapy 06/2023 - 11/2006
7	Transplantation 01/2023 - 03/2007
6	Aftercare (After-Treatment) 05/2024 - 01/2012
5	Stem Cell Transplantation 11/2017 - 10/2009
3	Bone Marrow Transplantation (Transplantation, Bone Marrow) 02/2012 - 12/2009
1	Orthopedic Procedures 04/2023
1	Splenectomy 10/2022